Deep Transcranial Magnetic Stimulation of the Dorsolateral Prefrontal Cortex in Alcohol Use Disorder Patients: Effects on Dopamine Transporter Availability and Alcohol Intake
Addolorato G., Antonelli M., Cocciolillo F., Vassallo G., Tarli C., Sestito L., Mirijello A., Ferrulli A., Pizzuto D.3, Camardese G., Miceli A., Diana M., Giordano A., Gasbarrini A., Di Giuda D.
A recent study performed in Italy investigated the efficacy of a Brainsway deep TMS H-coil, in the treatment of 14 alcohol use disorder patients, and the effects on the brain as reflected in Single-photon emission computed tomography (SPECT), an imaging method which detects concentrations of specific molecules. The study compared real deep TMS and sham (placebo) treatments of 4 weeks. It was found that only the real treatment led to a significant reduction in alcohol intake. Moreover, at baseline significant brain differences were seen in SPECT between patients and healthy subjects. After 4 weeks of treatment, real deep TMS led to significant brain changes as seen by SPECT, and the patients parameters became similar to healthy subjects.Read More
Shimizu et al. Efficacy of deep rTMS for neuropathic pain in the lower limb: a randomized, double-blind crossover trial of an H-coil and figure-8 coil
A recent study performed in Japan compared the safety and efficacy of a Brainsway deep TMS H-coil, a standard figure-8 TMS coil and a sham coil (placebo) for the treatment of 18 patients suffering from neuropathic pain. All patients received all three types of treatment in a crossover design. It was found that only the deep TMS H-coil induced significant pain improvements, while the results of the figure-8 were not significantly different than the sham. The treatment was well tolerated and no serious adverse events were reported.Read More
Roth, Y., Zangen, A., & Hallett, M. (2002). Journal of Clinical Neurophysiology, 19(4), 361-370.
This paper introduces, for the first time, the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil. The paper illustrates the considerations relevant to the design of the coil and compares the H-coil to a standard coil using a model of the human head.Read More
Three-Dimensional Distribution of the Electric Field Induced in the Brain by Transcranial Magnetic Stimulation Using Figure-8 and Deep H-Coils
Roth, Y., Amir, A., Levkovitz, Y., & Zangen, A. (2007). Journal of Clinical Neurophysiology, 24(1), 31-38.
This study compares the penetration depths of two different Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coils and a standard coil (Figure 8 coil). In the study, electrical fields of H-coils and of a Figure 8 coil were measured using a head model. This study demonstrates that the H-coil is able to reach significantly deeper brain areas than those reached by the figure-of-8 coil. Also, it was shown that the H-coils allow for stimulation of several brain regions at the same time.Read More
Roth, Y., Padberg, F., & Zangen, A. (2007). In “Transcranial Brain Stimulation for Treatment of Psychiatric Disorders” (Vol. 23).
This book chapter describes the biological and physical components that participate in the effects of Brainsway®'s Deep TMS (Transcranial Magnetic Stimulation) H-Coil for brain stimulation.Read More
Zangen, A., Roth, Y., Voller, B., & Hallett, M. (2005). Clinical neurophysiology, 116(4), 775-779
This study compares the penetration depths of the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil to a standard coil (figure 8) in healthy individuals. The study tested the efficacy, and some issues related to safety, of the H-coil, on healthy volunteers.Read More
Levkovitz, Y., Roth, Y., Harel, E. V., Braw, Y., Sheer, A., & Zangen, A. (2007). Clinical Neurophysiology, 118(12), 2730-2744.
This study examined possible effects of different Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coils and different stimulation parameters on healthy individuals. Several parameters relating to health, cognitive and emotional issues were checked .Results were also compared to a standard coil (figure 8) and to a sham coil. This study demonstrated that brain stimulation using the H-coil is feasible, safe and without adverse consequences.Read More
Transcranial Magnetic Stimulation induces increases in extracellular levels of dopamine and glutamate in the nucleus accumbens.
Zangen, A., & Hyodo, K. (2002). Neuroreport, 13(18), 2401-2405.
Deep transcranial magnetic stimulation as a treatment for psychiatric disorders: A comprehensive review
Bersani, F. S., Minichino, A., Enticott, P. G., Mazzarini, L., Khan, N., Antonacci, G., & Biondi, M. (2013). European Psychiatry, 28(1), 30-39.
This paper reviews the work done so far using the Brainsway® Deep TMS (Deep Transcranial Magnetic Stimulation) H-coil, and demonstrates the biological and physical components that participate in the effects generated by Deep Transcranial Magnetic Stimulation; both in general terms and for specific psychiatry disorders.Read More
Deep transcranial magnetic stimulation over the prefrontal cortex: Evaluation of antidepressant and cognitive effects in depressive patients
Levkovitz, Y., Harel, E. V., Roth, Y., Braw, Y., Most, D., Katz, L. N., & Zangen, A. (2009). Brain Stimulation, 2(4), 188-200.
This is the first clinical study using the Brainsway® Deep TMS (Transcranial Magnetic Stimulation) H-coil for deep brain stimulation. This large scale study examined the effect of H-coil on patients suffering from drug-resistant depression. The study found a significant improvement in HDRS scores in the cases of high-intensity stimulation.Read More